Search results for " midline"

showing 5 items of 5 documents

Exploiting Gangliosides for the Therapy of Ewing’s Sarcoma and H3K27M-Mutant Diffuse Midline Glioma

2021

Simple Summary Osteosarcoma, Ewing’s sarcoma, and H3K27M-mutant diffuse midline glioma are rare but aggressive malignancies occurring mainly in children. Due to their rareness and often fatal course, drug development is challenging. Here, we repurposed the existing drugs dinutuximab and eliglustat and investigated their potential to directly target or indirectly modulate the tumor cell-specific ganglioside GD2. Our data suggest that targeting and/or modulating tumor cell-specific GD2 may offer a new therapeutic strategy for the above mentioned tumor entities. Abstract The ganglioside GD2 is an important target in childhood cancer. Nevertheless, the only therapy targeting GD2 that is approve…

0301 basic medicineCancer Researchlcsh:RC254-282Article03 medical and health sciences0302 clinical medicineNeuroblastomaGliomaosteosarcomaH3K27M-mutant diffuse midline gliomamedicineGangliosidegangliosidebusiness.industrydinutuximabDinutuximabEwing's sarcomaCancerGD2eliglustatlcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensmedicine.disease030104 developmental biologyOncologyganglioside; GD2; dinutuximab; eliglustat; miglustat; H3K27M-mutant diffuse midline glioma; Ewing’s sarcoma; osteosarcoma030220 oncology & carcinogenesisCancer researchmiglustatSarcomaEwing’s sarcomabusinessEliglustatCancers; Volume 13; Issue 3; Pages: 520
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A customized dental CT software for automatic correction of patient positioning error and detection of jaw midline

2011

CT Dentascan jaw midline
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Linfoma angiocéntrico localizado en paladar

2001

Resumen Los linfomas angiocentricos son neoplasias muy poco frecuentes en nuestra area geografica. Suelen presentarse en la region oronasal como lesiones de tipo necrotico, en concreto en la zona mediofacial, con una evolucion rapida y un pronostico sombrio. Inmunohistoquimicamente se ha detectado que en estas neoplasias las celulas malignas corresponden a linfocitos T. Ademas estudios recientes apoyan la hipotesis del posible papel del virus de Epstein-Barr como posible factor etiologico. Presentamos en este articulo el caso clinico de un hombre de 67 anos con una lesion ulcerada en el paladar, de corto tiempo de evolucion y que tras estudio histopatologico e inmunohistoquimico se confirmo…

Otorhinolaryngologybusiness.industrymedicinemedicine.diseasebusinessLethal midline granulomaHumanitiesActa Otorrinolaringológica Española
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Percepción actual de la estética de la sonrisa

2020

Introducción: La belleza de una sonrisa constituye un sentimiento altamente subjetivo, y por ello los ideales de una sonrisa bonita pueden ser extensamente distintos y variables en la población. El objetivo de este estudio fue determinar los parámetros ideales de algunos componentes de la sonrisa, e igualmente conocer si la percepción estética de los mismos varía según profesionales de la odontología y público general, así como entre diestros y zurdos. Los aspectos de la sonrisa estudiados fueron: escalón vertical entre incisivos central y lateral, exposición gingival, forma de los dientes y desviación de línea media dental tanto hacia el lado derecho como izquierdo. Material y método: La m…

UNESCO::CIENCIAS MÉDICASgingival widthdental shapedental midline:CIENCIAS MÉDICAS [UNESCO]dental esthetics
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Incidence, severity and orthodontic treatment difficulty index of impacted canines in Saudi population

2018

Background The objective of this study was to assess the incidence, severity and orthodontic treatment difficulty of impacted maxillary canines in Saudi population. Material and methods This retrospective study included an investigation of panoramic radiographs for patients attended College of Dentistry, Jazan University, Saudi Arabia. The incidence of canine impaction and orthodontic treatment difficulty index of maxillary canine impaction was assessed based on; (1) patient age, (2) vertical position, (3) buccolingual position, (4) horizontal position, (5) incisors alignment, (6) canine space, (7) midline coincidence, (8) rotation of impacted tooth. Statistical analyses were calculated by …

education.field_of_studybusiness.industryImpacted toothImpactionResearchIncidence (epidemiology)PopulationMaxillary canineDentistryOrthodontics030206 dentistry030204 cardiovascular system & hematologyDental midline:CIENCIAS MÉDICAS [UNESCO]Canine space03 medical and health sciences0302 clinical medicinemedicine.anatomical_structureIncisorUNESCO::CIENCIAS MÉDICASmedicinebusinesseducationGeneral Dentistry
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